Discussion of a Recent Paper on Sporadic Inclusion Body
نویسنده
چکیده
The findings in a recent paper (1, also see 2) support the idea that the sporadic Inclusion Body Myositis (sIBM) is an autoimmune disease—an idea that has been in doubt because some drugs that suppress the immune system (and are used to treat other autoimmune conditions) have been ineffective in sIBM patients. Although sIBM is characterized by muscle inflammation associated with T cells, the presence of T cells in muscle fibers could be a response to whatever is causing the muscle weakness, rather than the original cause of the disease.
منابع مشابه
Inclusion-body myositis, a multifactorial muscle disease associated with aging: current concepts of pathogenesis.
PURPOSE OF REVIEW Sporadic inclusion-body myositis, the most common muscle disease of older persons, has no known cause or persistently beneficial treatment. The unfolding pathogenesis could lead to new treatment strategies and it is now of growing interest among clinicians and basic scientists. About 100 papers related to the subject were published in 2006 and the first part of 2007 (we cite o...
متن کاملInclusion body myositis: new insights into pathogenesis.
PURPOSE OF REVIEW The pathogenesis of sporadic inclusion body myositis is complex and the disease has a relentless course. Recent observations regarding possible mechanisms of disease may provide targets for therapy. RECENT FINDINGS Evidence is strengthening that specific T-cell and B-cell responses are ongoing in skeletal muscle in sporadic inclusion body myositis and that cytokines and chem...
متن کاملInclusion body myositis: current pathogenetic concepts and diagnostic and therapeutic approaches.
Inclusion body myositis is the most common acquired muscle disease in older individuals, and its prevalence varies among countries and ethnic groups. The aetiology and pathogenesis of sporadic inclusion body myositis are still poorly understood; however genetic factors, ageing, and environmental triggers might all have a role. Unlike other inflammatory myopathies, sporadic inclusion body myosit...
متن کاملSporadic inclusion body myositis - a myodegenerative disease or an inflammatory myopathy.
Sporadic inclusion body myositis (sIBM) is an insidious late-onset progressive myopathy that typically affects patients over the age of 50. Clinically, patients develop a characteristic pattern of weakness that affects the forearm flexors and knee extensors. Muscle biopsy, often utilized in the diagnosis, demonstrates a chronic myopathy with mixed pathologies harbouring intramyofiber protein in...
متن کاملSporadic inclusion body myositis: an unsolved mystery.
Sporadic inclusion body myositis (sIBM) is considered to be the most common acquired muscle disease associated with aging. It is a disabling disorder still without effective treatment. sIBM causes weakness and atrophy of the distal and proximal muscles. Involvement of quadriceps and deep finger flexors are clues to early diagnosis. Dysphagia in the course of the disease is common. Muscle biopsy...
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تاریخ انتشار 2016